2025
Kim B, Hosn RR, Remba T, Dye J, Mak H, Jeong JY, Cornwall-Brady M, Abraham W, Maiorino L, Melo MB, Li B, Zhang Y, Dong Y, Irvine DJ. Targeted suppression of type 1 interferon signaling during RNA delivery enhances vaccine-elicited immunity. In Revision.
Cui Y, Phuong K, Abdelfattah N, Temple H, Maiorino L, Kim B, Dye J, Yu KKH, Irvine DJ, White FM. Quantitative cell type specific immunopeptidome analysis during macrophage and tumor co-evolution reveals therapeutic MHC-I restricted peptides in glioblastoma. Submitted.
Das Adhikari U, Froehle LM, Pipkin AN, Baharlou H, Linder AH, Shah P, Hussey A, Zhang Q, Nyquist S, Khawaled S, Chi F, Goswami S, Dieffenbach TJ, Read BJ, Kim B, Irvine DJ, Ladinsky MS, Bjorkman PJ, Asowata O, Madela FG, Khader S, Shalek AK, Ghebremichael M, Kloverpris HN, Ringel AE, Yilmaz OH, Kwon DS. PPARγ downregulation in colonic CD8+ T cells results in epithelial barrier disruption in people with HIV on antiretroviral therapy. bioRxiv 2024.10.02.616363; doi: 10.1101/2024.10.02.616363. Submitted.
Hollett G, Fan R, Kumeria T, Leonard H, Kim B, Martin TR, Ipekci I, Wang J, Byun J, Chan N, Pierron A, Moore CE, Ayres J, Sailor MJ. Longer Acting Injectable: Continuous, Linear Release of Progestin Contraceptive from an Oxidized Porous Silicon Host. Adv Healthc Mater. doi: 10.1002/adhm.202403802 (2025).
Buckley M, Araínga M, Maiorino L, Pires IS, Kim B, Michaels KK, Dye J, Qureshi K, Zhang Y, Mak H, Villinger F, Schief WR, Steichen JM, Irvine DJ. Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates. Mol Ther. doi: 10.1016/j.ymthe.2025.01.008 (2025).
Prior Publications
Pires IS, Hostetler A, Covarrubias G, Carlo IS, Suggs JR, Kim B, Irvine DJ, Hammond PT. Charge-Stabilized Nanodiscs as a New Class of Lipid Nanoparticles. Adv Mater. doi: 10.1002/adma.202408307 (2024).
Jiang K, Yan Z, Di Bernardo M, Sgrizzi S, Viliger L, Kayabolen A, Kim B, Carscadden J, Hiraizumi M, Nishimasu H, Gootenberg J, Abudayyeh O. Rapid in silico directed evolution by a protein language model with EVOLVEpro. Science. doi: 10.1126/science.adr6006 (2024).
Roerden M, Castro AB, Cui Y, Harake N, Kim B, Dye J, Maiorino L, White FM, Irvine DJ, Litchfield K, Spranger S. Neoantigen architectures define immunogenicity and drive immune evasion of sub-clonal tumors. J Immunother Cancer. doi: 10.1136/jitc-2024-010249 (2024).
Nguyen KB, Roerden M, Copeland CJ, Backlund CM, Klop-Packel NG, Remba T, Kim B, Singh NK, Birnbaum ME, Irvine DJ, Spranger S. Decoupled neoantigen cross-presentation in tumors with high intratumor heterogeneity reduces dendritic cell activation to limit anti-tumor immunity. eLife. doi: 10.7554/eLife.85263 (2023).
Backlund C*, Jalili S*, Kim B*, Irvine DJ. Biomaterials-Mediated Engineering of the Immune System. Annu Rev Immunol. doi: 10.1146/annurev-immunol-101721-040259. PMID: 36696570 (2023).
*Co-first author
Pires IS, Ni K, Melo MB, Li N, Ben-Akiva E, Maiorino L, Dye J, Rodrigues KA, Yun DS, Kim B, Hosn RR, Hammond PT, Irvine D. Controlled Lipid Self-Assembly for Scalable Manufacturing of Next-Generation Immune Stimulating Complexes. Chem Eng J. doi: 10.1016/j.cej.2023.142664 (2023).
Kim B, Hosn RR, Remba T, Yun D, Li N, Abraham W, Melo MB, Cortes M, Li B, Zhang Y, Dong Y, Irvine DJ. Optimization of Storage Condition for RNA-loaded Lipid Nanoparticle Vaccines. J Control Release. doi: 10.1016/j.jconrel.2022.11.022 (2022).
Cover Article
Kim B, Yang Q, Chan LW, Bhatia S, Ruoslahti E, Sailor MJ. Fusogenic porous silicon nanoparticles as a broad-spectrum immunotherapy against bacterial infections. Nanoscale Horiz. doi: 10.1039/D0NH00624F (2021).
Kumeria T, Wang J, Kim B, Park J, Zuidema J, Klempner M, Cavacini L, Wang Y, Sailor MJ. Enteric Polymer-Coated Porous Silicon Nanoparticles for Site-Specific Oral Delivery of IgA Antibody. ACS Biomater Sci Eng. doi: 10.1021/acsbiomaterials.0c01313 (2020).
Robbiano V, Mariani S, Iglio R, La Mattina AA, Wang J, Kim B, Sailor MJ, Barillaro G. Moldless printing of silicone lenses with embedded nanostructured optical filters. Adv Funct Mater. 30 (4), 1906836, doi: 10.1002/adfm.201906836 (2019).
Kim B, Park J, Sailor MJ., Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery. Adv Mater. 1903637, doi: 10.1002/adma.201903637 (2019).
Advanced Materials Hall of Fame
Kim B, Sun S, Varner JA, Howell SB, Ruoslahti E, Sailor MJ. Securing the Payload, Finding the Cell, Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for More Effective Delivery of siRNA Therapies. Adv Mater. 31, 1902952, doi: 10.1002/adma.201902952 (2019).
Kim B, Sailor MJ. Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery. J Vis Exp. (146), e59440, doi: 10.3791/59440 (2019).
Kim B*, Pang H*, Kang J, Park J, Ruoslahti E, Sailor MJ. Immunogene therapy with fusogenic nanoparticles modulates macrophage response to Staphylococcus aureus. Nat Commun. 9(1), 1969, doi: 10.1038/s41467-018-04390-7 (2018).
*Co-first Author
Hussain S, Joo J, Kang J, Kim B, Braun GB, She Z, Kim D, Mann AP, Mölder T, Teesalu T, Carnazza S, Guglielmino S, Sailor MJ, Ruoslahti E. Antibiotic-loaded nanoparticles targeted to the site of infection enhance antibacterial efficacy. Nat Biomed Eng, 2(2), 95-103, doi: 10.1038/s41551-017-0187-5 (2018).
Lee J, Kim J, Jeong M, Lee H, Goh U, Kim H, Kim B, Park JH. Liposome-based engineering of cells to package hydrophobic compounds in membrane vesicles for tumor penetration. Nano Lett. 15, 2938-2944, doi: 10.1021/nl5047494 (2015).
Quan YH, Kim B, Park JH, Choi Y, Choi YH, Kim, HK. Highly sensitive and selective anticancer effect by conjugated HA-cisplatin in non-small cell lung cancer overexpressed with CD44. Exp Lung Res. 40, 475-484, doi: 10.3109/01902148.2014.905656 (2014).