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Research
Kim Lab develops cutting-edge RNA therapeutics by advancing high-throughput screening, investigating biological barriers to RNA delivery, and engineering innovative RNA drugs for cancer and other diseases.
High-Throughput Screening of RNA Therapies
We develop high-throughput platforms to rapidly evaluate RNA delivery systems. By screening large libraries of lipid nanoparticles and target biologies in parallel, we aim to identify optimal formulations and biological parameters that enhance the delivery of RNA therapeutics to specific tissues and cell types, particularly in cancer. This approach accelerates the discovery process and provides crucial insights into how different delivery methods perform in vivo.
Mechanistic Insights into
RNA Therapeutics
We explore the intricate interactions between RNA delivery systems and the biological environment. This research focuses on understanding how factors like cellular uptake, immune responses, and tissue characteristics impact the success of RNA therapies. By identifying the biological and molecular barriers that hinder RNA delivery, we aim to develop strategies to improve therapeutic efficiency and overcome resistance, particularly in solid tumors.
Engineering Next-Generation RNA Therapeutics
The lab is also dedicated to using synthetic biology to design innovative RNA constructs that integrate gene silencing and protein expression into a single therapeutic platform. These multifunctional RNA therapeutics hold immense potential for treating complex diseases like cancer by simultaneously targeting multiple pathways. Our goal is to develop more effective, stable, and clinically translatable RNA-based treatments that can revolutionize personalized medicine.
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